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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C153095
http://purl.obolibrary.org/obo/NCIT_C153095
|
|---|---|
| Preferred Name | Epitinib Succinate |
| Definitions |
The succinate salt form of epitinib, an orally available epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon administration, epitinib inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may lead to induction of cell death and inhibition of tumor growth in EGFR-overexpressing tumor cells. EGFR is a receptor tyrosine kinase (RTK) that is overexpressed in certain tumor types and plays a key role in tumor cell proliferation and vascularization.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The succinate salt form of epitinib, an orally available epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon administration, epitinib inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may lead to induction of cell death and inhibition of tumor growth in EGFR-overexpressing tumor cells. EGFR is a receptor tyrosine kinase (RTK) that is overexpressed in certain tumor types and plays a key role in tumor cell proliferation and vascularization. |
|---|---|
| label | Epitinib Succinate
|
| prefLabel | Epitinib Succinate
|
| in_subset | |
| Preferred_Name | Epitinib Succinate
|
| Is_Value_For_GDC_Property | |
| Maps_To | Epitinib Succinate
|
| PDQ_Open_Trial_Search_ID | 793471
|
| FDA_UNII_Code | 2138WW3F3R
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| prefixIRI | NCIT:C153095
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| NCI_Drug_Dictionary_ID | 793471
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| Contributing_Source | FDA
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| subClassOf | |
| code | C153095
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| type | |
| PDQ_Closed_Trial_Search_ID | 793471
|
| Semantic_Type | Pharmacologic Substance
|
| CAS_Registry | 2252334-12-4
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| NCI_META_CUI | CL554354
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