Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C152976
http://purl.obolibrary.org/obo/NCIT_C152976
|
|---|---|
| Preferred Name | AXL Inhibitor DS-1205c |
| Definitions |
An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, DS-1205c targets, binds to and prevents the activation of AXL. This blocks AXL-mediated signal transduction pathways and inhibits tumor cell proliferation and migration. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types. It plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, DS-1205c targets, binds to and prevents the activation of AXL. This blocks AXL-mediated signal transduction pathways and inhibits tumor cell proliferation and migration. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types. It plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis. |
|---|---|
| prefLabel | AXL Inhibitor DS-1205c
|
| label | AXL Inhibitor DS-1205c
|
| NCI_META_CUI | CL554179
|
| PDQ_Closed_Trial_Search_ID | 793863
|
| code | C152976
|
| Has_Target | |
| prefixIRI | NCIT:C152976
|
| in_subset |
See more
See less
|
| Display_Name | AXL Inhibitor DS-1205c
|
| Preferred_Name | AXL Inhibitor DS-1205c
|
| Contributing_Source | CTRP
|
| Maps_To | AXL Inhibitor DS-1205c
|
| NCI_Drug_Dictionary_ID | 793863
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 793863
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |