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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1522
http://purl.obolibrary.org/obo/NCIT_C1522
|
|---|---|
| Preferred Name | Troglitazone |
| Definitions |
An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04) |
|---|---|
| prefLabel | Troglitazone
|
| label | Troglitazone
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| CHEBI_ID | CHEBI:9753
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| PDQ_Closed_Trial_Search_ID | 42706
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| code | C1522
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| prefixIRI | NCIT:C1522
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| in_subset | |
| Preferred_Name | Troglitazone
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| FDA_UNII_Code | I66ZZ0ZN0E
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| Contributing_Source | FDA
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| Maps_To | Troglitazone
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| CAS_Registry | 97322-87-7
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| NCI_Drug_Dictionary_ID | 42706
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| Legacy Concept Name | Troglitazone
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42706
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0245514
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| Delete | Subject | Author | Type | Created |
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