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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1521
http://purl.obolibrary.org/obo/NCIT_C1521
|
|---|---|
| Preferred Name | Losoxantrone |
| Definitions |
An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin. |
|---|---|
| prefLabel | Losoxantrone
|
| label | Losoxantrone
|
| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 41809
|
| code | C1521
|
| prefixIRI | NCIT:C1521
|
| in_subset | |
| Preferred_Name | Losoxantrone
|
| FDA_UNII_Code | 47KPH00809
|
| Contributing_Source | FDA
|
| Chemical_Formula | C22H27N5O4
|
| Maps_To | Losoxantrone
|
| CAS_Registry | 88303-60-0
|
| NSC Number | 357885
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| NCI_Drug_Dictionary_ID | 41809
|
| Legacy Concept Name | Losoxantrone
|
| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antipyrazoles.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41809
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0245032
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| Delete | Subject | Author | Type | Created |
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