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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1519
http://purl.obolibrary.org/obo/NCIT_C1519
|
|---|---|
| Preferred Name | Roquinimex |
| Definitions |
A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04) |
|---|---|
| prefLabel | Roquinimex
|
| label | Roquinimex
|
| PDQ_Closed_Trial_Search_ID | 41410
|
| code | C1519
|
| prefixIRI | NCIT:C1519
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| in_subset | |
| Preferred_Name | Roquinimex
|
| FDA_UNII_Code | 372T2944C0
|
| Contributing_Source | FDA
|
| Chemical_Formula | C18H16N2O3
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| Maps_To | Roquinimex
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| CAS_Registry | 84088-42-6
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| NCI_Drug_Dictionary_ID | 41410
|
| Legacy Concept Name | Roquinimex
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41410
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0244748
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| Delete | Subject | Author | Type | Created |
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