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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C151407
http://purl.obolibrary.org/obo/NCIT_C151407
|
|---|---|
| Preferred Name | Flt3/MerTK Inhibitor MRX-2843 |
| Definitions |
An orally bioavailable inhibitor of two receptor tyrosine kinases (RTKs), FMS-like tyrosine kinase-3 (Flt3; CD135; fetal liver kinase-2; Flk2) and tyrosine-protein kinase Mer (MerTK; proto-oncogene c-Mer; Mer), with potential antineoplastic activity. Upon administration, MRX-2843 targets and binds to both Flt3 and MerTK. This prevents ligand-dependent phosphorylation and activation of Flt3 and MerTK, which inhibits the activation of their downstream signaling pathways. This induces apoptosis and inhibits proliferation of Flt3- and/or MerTK-overexpressing tumor cells. Flt3 and MerTK, are overexpressed in certain tumor cell types and play key roles in tumor cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of two receptor tyrosine kinases (RTKs), FMS-like tyrosine kinase-3 (Flt3; CD135; fetal liver kinase-2; Flk2) and tyrosine-protein kinase Mer (MerTK; proto-oncogene c-Mer; Mer), with potential antineoplastic activity. Upon administration, MRX-2843 targets and binds to both Flt3 and MerTK. This prevents ligand-dependent phosphorylation and activation of Flt3 and MerTK, which inhibits the activation of their downstream signaling pathways. This induces apoptosis and inhibits proliferation of Flt3- and/or MerTK-overexpressing tumor cells. Flt3 and MerTK, are overexpressed in certain tumor cell types and play key roles in tumor cell proliferation and survival. |
|---|---|
| prefLabel | Flt3/MerTK Inhibitor MRX-2843
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| label | Flt3/MerTK Inhibitor MRX-2843
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| NCI_META_CUI | CL553239
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| PDQ_Closed_Trial_Search_ID | 793562
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| code | C151407
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| Has_Target | |
| prefixIRI | NCIT:C151407
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| in_subset |
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| Display_Name | Flt3/MerTK Inhibitor MRX-2843
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| Preferred_Name | Flt3/MerTK Inhibitor MRX-2843
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| FDA_UNII_Code | 2MT30EHI63
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Flt3/MerTK Inhibitor MRX-2843
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| CAS_Registry | 1429882-07-4
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| NCI_Drug_Dictionary_ID | 793562
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 793562
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| Semantic_Type | Pharmacologic Substance
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