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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C150552
http://purl.obolibrary.org/obo/NCIT_C150552
|
|---|---|
| Preferred Name | SERD G1T48 |
| Definitions |
An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD G1T48 specifically targets and binds to the estrogen receptor alpha (ERalpha; ERa; ESR1) and induces a conformational change that promotes ERalpha degradation and downregulation. This prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD G1T48 specifically targets and binds to the estrogen receptor alpha (ERalpha; ERa; ESR1) and induces a conformational change that promotes ERalpha degradation and downregulation. This prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing cancer cells. |
|---|---|
| prefLabel | SERD G1T48
|
| label | SERD G1T48
|
| NCI_META_CUI | CL552249
|
| PDQ_Closed_Trial_Search_ID | 793441
|
| code | C150552
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| Has_Target | |
| prefixIRI | NCIT:C150552
|
| in_subset | |
| Display_Name | SERD G1T48
|
| Preferred_Name | SERD G1T48
|
| Contributing_Source | CTRP
|
| Maps_To | SERD G1T48
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| NCI_Drug_Dictionary_ID | 793441
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 793441
|
| Semantic_Type | Pharmacologic Substance
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