Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C150507
http://purl.obolibrary.org/obo/NCIT_C150507
Preferred Name

SMAC Mimetic BI 891065
Definitions
A mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins), with potential antineoplastic activity. Upon administration, Smac mimetic BI 891065 targets and binds to the Smac binding groove on IAPs, including the caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting certain caspases.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins), with potential antineoplastic activity. Upon administration, Smac mimetic BI 891065 targets and binds to the Smac binding groove on IAPs, including the caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting certain caspases.
prefLabel
SMAC Mimetic BI 891065
label
SMAC Mimetic BI 891065
NCI_META_CUI
CL552291
PDQ_Closed_Trial_Search_ID
793013
code
C150507
prefixIRI
NCIT:C150507
in_subset
Preferred_Name
SMAC Mimetic BI 891065
Maps_To
SMAC Mimetic BI 891065
NCI_Drug_Dictionary_ID
793013
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
793013
Semantic_Type
Pharmacologic Substance
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