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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C150430
http://purl.obolibrary.org/obo/NCIT_C150430
|
|---|---|
| Preferred Name | Radgocitabine Hydrochloride |
| Definitions |
The hydrochloride salt form of radgocitabine, an analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt form of radgocitabine, an analogue of the nucleoside deoxycytidine with potential antineoplastic activity. Upon administration, radgocitabine is incorporated into DNA and directly inhibits the activity of DNA polymerase, which may result in inhibition of DNA replication and cell cycle arrest in the S and G2/M phases, DNA fragmentation, and tumor cell apoptosis. |
|---|---|
| prefLabel | Radgocitabine Hydrochloride
|
| label | Radgocitabine Hydrochloride
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| NCI_META_CUI | CL552242
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| code | C150430
|
| prefixIRI | NCIT:C150430
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| in_subset | |
| Preferred_Name | Radgocitabine Hydrochloride
|
| FDA_UNII_Code | VSS4ZDZ2IE
|
| Contributing_Source | FDA
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| Maps_To |
Radgocitabine Hydrochloride
Deoxycytidine Analogue TAS-109 Hydrochloride
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| CAS_Registry | 134665-72-8
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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