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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C150383
http://purl.obolibrary.org/obo/NCIT_C150383
|
|---|---|
| Preferred Name | FGFR1/2/3 Inhibitor HMPL-453 |
| Definitions |
An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon administration, FGFR inhibitor HMPL-453 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases (RTKs) upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon administration, FGFR inhibitor HMPL-453 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases (RTKs) upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival. |
|---|---|
| label | FGFR1/2/3 Inhibitor HMPL-453
|
| prefLabel | FGFR1/2/3 Inhibitor HMPL-453
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| in_subset | |
| Preferred_Name | FGFR1/2/3 Inhibitor HMPL-453
|
| Is_Value_For_GDC_Property | |
| Maps_To | FGFR1/2/3 Inhibitor HMPL-453
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| PDQ_Open_Trial_Search_ID | 792789
|
| Has_Target | |
| prefixIRI | NCIT:C150383
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| NCI_Drug_Dictionary_ID | 792789
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| subClassOf | |
| code | C150383
|
| type | |
| PDQ_Closed_Trial_Search_ID | 792789
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| Semantic_Type | Pharmacologic Substance
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| NCI_META_CUI | CL552165
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