Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1501
http://purl.obolibrary.org/obo/NCIT_C1501
Preferred Name

Phenyl Acetate
Definitions
An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibition, and apoptosis in tumor cells. Implicated mechanisms of action include decreased protein prenylation, activation of the peroxisome proliferation-activated receptors, inhibition of DNA methylation, and depletion of glutamine. (NCI04)
prefLabel
Phenyl Acetate
label
Phenyl Acetate
CHEBI_ID
CHEBI:8082
PDQ_Closed_Trial_Search_ID
41664
code
C1501
prefixIRI
NCIT:C1501
in_subset
Preferred_Name
Phenyl Acetate
FDA_UNII_Code
355G9R500Y
Contributing_Source
FDA
Chemical_Formula
C8H8O2
Maps_To
Phenyl Acetate
CAS_Registry
122-79-2
NSC Number
27795
NCI_Drug_Dictionary_ID
41664
Legacy Concept Name
Phenyl_Acetate
type
ALT_DEFINITION
A drug being studied in the treatment of cancer.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41664
Accepted_Therapeutic_Use_For
Adjunctive therapy for the prevention and treatment of hyperammonemia in the chronic management of patients with urea cycle enzymopathy
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0220893
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