Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1493
http://purl.obolibrary.org/obo/NCIT_C1493
Preferred Name

Satraplatin
Definitions
An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis.
prefLabel
Satraplatin
label
Satraplatin
PDQ_Closed_Trial_Search_ID
42141
code
C1493
prefixIRI
NCIT:C1493
in_subset
Display_Name
Satraplatin
Preferred_Name
Satraplatin
FDA_UNII_Code
8D7B37T28G
Contributing_Source
CTRP
FDA
Chemical_Formula
C6H13N.2C2H3O2.2Cl.Pt.H3N
Maps_To
Satraplatin
CAS_Registry
129580-63-8
NCI_Drug_Dictionary_ID
42141
Legacy Concept Name
Satraplatin
type
ALT_DEFINITION
A substance being studied in the treatment of prostate and other types of cancer. It contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42141
Semantic_Type
Pharmacologic Substance
Inorganic Chemical
UMLS_CUI
C1142934
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display