Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Id http://purl.obolibrary.org/obo/NCIT_C1492
http://purl.obolibrary.org/obo/NCIT_C1492
Preferred Name

Sargramostim
Definitions
A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.
label
Sargramostim
prefLabel
Sargramostim
Legacy Concept Name
Sargramostim
in_subset
Preferred_Name
Sargramostim
Is_Value_For_GDC_Property
Display_Name
Sargramostim
Maps_To
Sargramostim
PDQ_Open_Trial_Search_ID
40566
UMLS_CUI
C0216231
FDA_UNII_Code
5TAA004E22
prefixIRI
NCIT:C1492
Accepted_Therapeutic_Use_For
Melanoma; Neutropenia-chemotherapy induced
NCI_Drug_Dictionary_ID
40566
Contributing_Source
CTRP
FDA
subClassOf
code
C1492
type
ALT_DEFINITION
A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.
PDQ_Closed_Trial_Search_ID
40566
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
CAS_Registry
123774-72-1
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