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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1492
http://purl.obolibrary.org/obo/NCIT_C1492
|
|---|---|
| Preferred Name | Sargramostim |
| Definitions |
A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. |
|---|---|
| prefLabel | Sargramostim
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| label | Sargramostim
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| PDQ_Closed_Trial_Search_ID | 40566
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| code | C1492
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| prefixIRI | NCIT:C1492
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| in_subset |
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| Display_Name | Sargramostim
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| Preferred_Name | Sargramostim
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| FDA_UNII_Code | 5TAA004E22
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Sargramostim
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| CAS_Registry | 123774-72-1
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| NCI_Drug_Dictionary_ID | 40566
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| Legacy Concept Name | Sargramostim
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| type | |
| ALT_DEFINITION | A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40566
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| Accepted_Therapeutic_Use_For | Melanoma; Neutropenia-chemotherapy induced
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0216231
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