Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1488
http://purl.obolibrary.org/obo/NCIT_C1488
Preferred Name

Aminocamptothecin
Definitions
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)
prefLabel
Aminocamptothecin
label
Aminocamptothecin
PDQ_Closed_Trial_Search_ID
41792
code
C1488
prefixIRI
NCIT:C1488
in_subset
Preferred_Name
Aminocamptothecin
FDA_UNII_Code
5MB77ICE2Q
Contributing_Source
FDA
Maps_To
Aminocamptothecin
CAS_Registry
86639-63-6
NSC Number
603071
NCI_Drug_Dictionary_ID
41792
Legacy Concept Name
Aminocamptothecin
type
ALT_DEFINITION
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
41792
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0214192
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