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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C148520
http://purl.obolibrary.org/obo/NCIT_C148520
|
|---|---|
| Preferred Name | Androgen Receptor Antagonist BAY 1161116 |
| Definitions |
An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist BAY 1161116 specifically binds to AR, inhibits AR activation, and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable antagonist of the androgen receptor (AR), with potential antineoplastic activity. Upon oral administration, AR antagonist BAY 1161116 specifically binds to AR, inhibits AR activation, and prevents AR-mediated signaling. This inhibits cell growth in AR-overexpressing tumor cells. AR is overexpressed in prostate cancers and is involved in proliferation, survival and chemoresistance of tumor cells. |
|---|---|
| prefLabel | Androgen Receptor Antagonist BAY 1161116
|
| label | Androgen Receptor Antagonist BAY 1161116
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| NCI_META_CUI | CL551148
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| PDQ_Closed_Trial_Search_ID | 792679
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| code | C148520
|
| prefixIRI | NCIT:C148520
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| in_subset | |
| Preferred_Name | Androgen Receptor Antagonist BAY 1161116
|
| Maps_To | Androgen Receptor Antagonist BAY 1161116
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| NCI_Drug_Dictionary_ID | 792679
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792679
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| Semantic_Type | Pharmacologic Substance
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