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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C148519
http://purl.obolibrary.org/obo/NCIT_C148519
|
|---|---|
| Preferred Name | Topical Celecoxib |
| Definitions |
A topical cream formulation containing celecoxib, a nonsteroidal anti-inflammatory drug (NSAID), with anti-inflammatory and potential keratolytic, chemopreventive and antineoplastic activities. Upon topical application to the affected area, celecoxib selectively binds to and inhibits cyclooxygenase-2 activity (COX-2), which may result in localized keratinocyte apoptosis. The breakdown of keratinocytes prevents their proliferation locally and may reduce tumor cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A topical cream formulation containing celecoxib, a nonsteroidal anti-inflammatory drug (NSAID), with anti-inflammatory and potential keratolytic, chemopreventive and antineoplastic activities. Upon topical application to the affected area, celecoxib selectively binds to and inhibits cyclooxygenase-2 activity (COX-2), which may result in localized keratinocyte apoptosis. The breakdown of keratinocytes prevents their proliferation locally and may reduce tumor cell proliferation. |
|---|---|
| label | Topical Celecoxib
|
| prefLabel | Topical Celecoxib
|
| in_subset | |
| Preferred_Name | Topical Celecoxib
|
| Is_Value_For_GDC_Property | |
| Maps_To | Topical Celecoxib
|
| PDQ_Open_Trial_Search_ID | 792678
|
| prefixIRI | NCIT:C148519
|
| NCI_Drug_Dictionary_ID | 792678
|
| subClassOf | |
| code | C148519
|
| type | |
| PDQ_Closed_Trial_Search_ID | 792678
|
| Semantic_Type | Pharmacologic Substance
|
| NCI_META_CUI | CL551149
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