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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1485
http://purl.obolibrary.org/obo/NCIT_C1485
|
|---|---|
| Preferred Name | Rubitecan |
| Definitions |
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04) |
|---|---|
| prefLabel | Rubitecan
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| label | Rubitecan
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| PDQ_Closed_Trial_Search_ID | 42528
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| code | C1485
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| prefixIRI | NCIT:C1485
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| in_subset | |
| Preferred_Name | Rubitecan
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| FDA_UNII_Code | H19C446XXB
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| Contributing_Source | FDA
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| Chemical_Formula | C20H15N3O6
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| Maps_To | Rubitecan
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| CAS_Registry | 91421-42-0
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| NSC Number | 603070
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| NCI_Drug_Dictionary_ID | 42528
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| Legacy Concept Name | Rubitecan
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| type | |
| ALT_DEFINITION | An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42528
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| Accepted_Therapeutic_Use_For | AIDs, pediatric; HIV infection, pediatric
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0213800
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