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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C148486
http://purl.obolibrary.org/obo/NCIT_C148486
|
|---|---|
| Preferred Name | Glofitamab |
| Definitions |
A bispecific monoclonal antibody, with potential antineoplastic activity. Glofitamab contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, glofitamab binds to both T-cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B-cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific monoclonal antibody, with potential antineoplastic activity. Glofitamab contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, glofitamab binds to both T-cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B-cells. |
|---|---|
| prefLabel | Glofitamab
|
| label | Glofitamab
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| NCI_META_CUI | CL551055
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| PDQ_Closed_Trial_Search_ID | 792571
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| code | C148486
|
| Has_Target | |
| prefixIRI | NCIT:C148486
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| in_subset |
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| Display_Name | Glofitamab
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| Preferred_Name | Glofitamab
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| FDA_UNII_Code | 06P3KLK2J8
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Glofitamab
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| CAS_Registry | 2229047-91-8
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| NCI_Drug_Dictionary_ID | 792571
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792571
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| Semantic_Type | Pharmacologic Substance
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