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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1482
http://purl.obolibrary.org/obo/NCIT_C1482
|
|---|---|
| Preferred Name | Squalamine Lactate |
| Definitions |
The lactate salt form of squalamine, an aminosterol isolated from tissues of the dogfish shark Squalus acanthias. Possessing anti-angiogenic properties, squalamine inhibits the sodium-hydrogen exchanger NHE3, resulting in suppression of endothelial cell proliferation and migration. This agent also has broad-spectrum antimicrobial properties. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The lactate salt form of squalamine, an aminosterol isolated from tissues of the dogfish shark Squalus acanthias. Possessing anti-angiogenic properties, squalamine inhibits the sodium-hydrogen exchanger NHE3, resulting in suppression of endothelial cell proliferation and migration. This agent also has broad-spectrum antimicrobial properties. (NCI04) |
|---|---|
| prefLabel | Squalamine Lactate
|
| label | Squalamine Lactate
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| PDQ_Closed_Trial_Search_ID | 43041
|
| code | C1482
|
| prefixIRI | NCIT:C1482
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| in_subset | |
| Preferred_Name | Squalamine Lactate
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| FDA_UNII_Code | 4WE915J1KX
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| Contributing_Source | FDA
|
| Chemical_Formula | C34H65N3O5S.C3H6O3.H2O
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| Maps_To | Squalamine Lactate
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| CAS_Registry | 320725-47-1
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| NSC Number | 715056
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| NCI_Drug_Dictionary_ID | 43041
|
| Legacy Concept Name | Squalamine
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| type | |
| ALT_DEFINITION | A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43041
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0213314
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| Delete | Subject | Author | Type | Created |
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