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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C148165
http://purl.obolibrary.org/obo/NCIT_C148165
|
|---|---|
| Preferred Name | Trastuzumab Conjugate BI-CON-02 |
| Definitions |
A conjugated form of trastuzumab, a humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2; ERBB2), with potential immunomodulating and antineoplastic activities. Upon administration, the trastuzumab conjugate BI-CON-02 targets and binds to HER2 on the tumor cell surface, thereby inducing both cytotoxic T-lymphocyte (CTL) and antibody-dependent cell-mediated cytotoxicity (ADCC) responses against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A conjugated form of trastuzumab, a humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2; ERBB2), with potential immunomodulating and antineoplastic activities. Upon administration, the trastuzumab conjugate BI-CON-02 targets and binds to HER2 on the tumor cell surface, thereby inducing both cytotoxic T-lymphocyte (CTL) and antibody-dependent cell-mediated cytotoxicity (ADCC) responses against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. |
|---|---|
| prefLabel | Trastuzumab Conjugate BI-CON-02
|
| label | Trastuzumab Conjugate BI-CON-02
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| NCI_META_CUI | CL550783
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| PDQ_Closed_Trial_Search_ID | 792543
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| code | C148165
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| prefixIRI | NCIT:C148165
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| in_subset | |
| Preferred_Name | Trastuzumab Conjugate BI-CON-02
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| Maps_To | Trastuzumab Conjugate BI-CON-02
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| NCI_Drug_Dictionary_ID | 792543
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792543
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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