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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1474
http://purl.obolibrary.org/obo/NCIT_C1474
|
|---|---|
| Preferred Name | Filgrastim |
| Definitions |
A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. |
|---|---|
| prefLabel | Filgrastim
|
| label | Filgrastim
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| PDQ_Closed_Trial_Search_ID | 41057
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| code | C1474
|
| prefixIRI | NCIT:C1474
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| in_subset |
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| Display_Name | Filgrastim
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| Preferred_Name | Filgrastim
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| FDA_UNII_Code | PVI5M0M1GW
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| Contributing_Source |
CTRP
FDA
PCDC
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| Maps_To | Filgrastim
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| CAS_Registry | 121181-53-1
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| NSC Number | 614629
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| NCI_Drug_Dictionary_ID | 41057
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| Legacy Concept Name | Filgrastim
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| type | |
| ALT_DEFINITION | A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that is a type of hematopoietic (blood-forming) agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41057
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| Accepted_Therapeutic_Use_For | Aplastic neutropenia; Bone marrow transplantation; Cancer patients receiving myelosuppressive chemotherapy; Congenital neutropenia; Idiopathic or cyclic neutropenia; Peripheral blood progenitor cell mobilization
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0210630
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