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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1472
http://purl.obolibrary.org/obo/NCIT_C1472
|
|---|---|
| Preferred Name | Bizelesin |
| Definitions |
A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04) |
|---|---|
| prefLabel | Bizelesin
|
| label | Bizelesin
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| PDQ_Closed_Trial_Search_ID | 42688
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| code | C1472
|
| prefixIRI | NCIT:C1472
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| in_subset | |
| Preferred_Name | Bizelesin
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| FDA_UNII_Code | L0O9OBI87E
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| Contributing_Source | FDA
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| Chemical_Formula | C43H36Cl2N8O5
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| Maps_To | Bizelesin
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| CAS_Registry | 129655-21-6
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| NSC Number | 615291
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| NCI_Drug_Dictionary_ID | 42688
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| Legacy Concept Name | Bizelesin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents. It is also an antitumor antibiotic.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42688
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0209891
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| Delete | Subject | Author | Type | Created |
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