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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C146860
http://purl.obolibrary.org/obo/NCIT_C146860
|
|---|---|
| Preferred Name | Elranatamab |
| Definitions |
A bispecific monoclonal antibody against human CD3, a T-cell surface antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. Upon administration, elranatamab binds to both CD3 on T-cells and BCMA expressed on malignant plasma cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific monoclonal antibody against human CD3, a T-cell surface antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. Upon administration, elranatamab binds to both CD3 on T-cells and BCMA expressed on malignant plasma cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival. |
|---|---|
| label | Elranatamab
|
| prefLabel | Elranatamab
|
| in_subset |
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| Preferred_Name | Elranatamab
|
| Is_Value_For_GDC_Property | |
| Display_Name | Elranatamab
|
| Maps_To | Anti-CD3/Anti-BCMA Bispecific Monoclonal Antibody PF-06863135
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| PDQ_Open_Trial_Search_ID | 792267
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| Has_Target | |
| FDA_UNII_Code | L0HR9A577V
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| prefixIRI | NCIT:C146860
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| NCI_Drug_Dictionary_ID | 792267
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C146860
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| type | |
| PDQ_Closed_Trial_Search_ID | 792267
|
| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 2408850-14-4
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| NCI_META_CUI | CL544825
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