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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C146820
http://purl.obolibrary.org/obo/NCIT_C146820
|
|---|---|
| Preferred Name | Tidutamab |
| Definitions |
A humanized, Fc domain-containing, bispecific monoclonal antibody targeting human CD3, a T-cell surface antigen, and somatostatin receptor 2 (SSTR2), a tumor-associated antigen (TAA) expressed on certain cancer cells, with potential antineoplastic activity. Upon administration, tidutamab binds to both T-cells and SSTR2-expressing cancer cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the SSTR2-expressing cancer cells. The inclusion of an Fc domain on the antibody prolongs the half-life of the bispecific antibody.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized, Fc domain-containing, bispecific monoclonal antibody targeting human CD3, a T-cell surface antigen, and somatostatin receptor 2 (SSTR2), a tumor-associated antigen (TAA) expressed on certain cancer cells, with potential antineoplastic activity. Upon administration, tidutamab binds to both T-cells and SSTR2-expressing cancer cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the SSTR2-expressing cancer cells. The inclusion of an Fc domain on the antibody prolongs the half-life of the bispecific antibody. |
|---|---|
| prefLabel | Tidutamab
|
| label | Tidutamab
|
| NCI_META_CUI | CL544867
|
| PDQ_Closed_Trial_Search_ID | 792257
|
| code | C146820
|
| Has_Target | |
| prefixIRI | NCIT:C146820
|
| in_subset |
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| Display_Name | Tidutamab
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| Preferred_Name | Tidutamab
|
| FDA_UNII_Code | 88635FW2QX
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Tidutamab
|
| CAS_Registry | 2148354-90-7
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| NCI_Drug_Dictionary_ID | 792257
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792257
|
| Semantic_Type | Pharmacologic Substance
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