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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C146779
http://purl.obolibrary.org/obo/NCIT_C146779
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|---|---|
| Preferred Name | Autologous TCR-engineered T-cells IMA201 |
| Definitions |
A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of autologous T-lymphocytes that are genetically modified with a lentiviral vector encoding a T-cell receptor (TCR) specific for an as of yet not identified tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration back into the patient, the autologous TCR-engineered T-cells IMA201 specifically recognize and bind to the TAA on cancer cells, which induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against the TAA-positive cancer cells. |
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| prefLabel | Autologous TCR-engineered T-cells IMA201
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| label | Autologous TCR-engineered T-cells IMA201
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| NCI_META_CUI | CL544786
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| PDQ_Closed_Trial_Search_ID | 792163
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| code | C146779
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| prefixIRI | NCIT:C146779
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| in_subset |
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| Display_Name | Autologous TCR-engineered T-cells IMA201
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| Preferred_Name | Autologous TCR-engineered T-cells IMA201
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| Contributing_Source | CTRP
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| Maps_To | Autologous TCR-engineered T-cells IMA201
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| NCI_Drug_Dictionary_ID | 792163
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792163
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| Semantic_Type | Pharmacologic Substance
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