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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C146711
http://purl.obolibrary.org/obo/NCIT_C146711
|
|---|---|
| Preferred Name | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM |
| Definitions |
A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against breast cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A vaccine consisting of irradiated allogeneic breast cancer cells, derived from the breast cancer cell line SV-BR-1 that are transfected with the immunostimulant granulocyte-macrophage colony-stimulating factor (GM-CSF; CSF2) gene, with potential immunostimulating and antineoplastic activities. Upon intradermal administration of the allogeneic GM-CSF-secreting breast cancer vaccine SV-BR-1-GM, the genetically-modified cells secrete GM-CSF. This potentiates a tumor-specific cytotoxic T-lymphocyte (CTL) immune response against breast cancer cells. |
|---|---|
| label | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM
|
| prefLabel | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM
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| in_subset |
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| Preferred_Name | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM
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| Is_Value_For_GDC_Property | |
| Display_Name | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM
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| Maps_To | Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM
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| PDQ_Open_Trial_Search_ID | 792158
|
| prefixIRI | NCIT:C146711
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| NCI_Drug_Dictionary_ID | 792158
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C146711
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| type | |
| PDQ_Closed_Trial_Search_ID | 792158
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| Semantic_Type | Immunologic Factor
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| NCI_META_CUI | CL544722
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