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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1464
http://purl.obolibrary.org/obo/NCIT_C1464
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|---|---|
| Preferred Name | Tirapazamine |
| Definitions |
A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04) |
|---|---|
| prefLabel | Tirapazamine
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| label | Tirapazamine
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| PDQ_Closed_Trial_Search_ID | 42158
|
| code | C1464
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| Has_Target | |
| prefixIRI | NCIT:C1464
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| in_subset |
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| Display_Name | Tirapazamine
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| Preferred_Name | Tirapazamine
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| FDA_UNII_Code | 1UD32YR59G
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C7H6N4O2
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| Maps_To | Tirapazamine
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| CAS_Registry | 27314-97-2
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| NSC Number | 130181
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| NCI_Drug_Dictionary_ID | 42158
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| Legacy Concept Name | Tirapazamine
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| type | |
| ALT_DEFINITION | A drug that makes tumor cells more sensitive to radiation therapy.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42158
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0208407
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