Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1461
http://purl.obolibrary.org/obo/NCIT_C1461
Preferred Name

Perillyl Alcohol
Definitions
A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. (NCI04)
label
Perillyl Alcohol
prefLabel
Perillyl Alcohol
Legacy Concept Name
Perillyl_Alcohol
in_subset
Preferred_Name
Perillyl Alcohol
Is_Value_For_GDC_Property
Chemical_Formula
C10H16O
Display_Name
Perillyl Alcohol
Maps_To
Perillyl Alcohol
PDQ_Open_Trial_Search_ID
42334
Has_Target
UMLS_CUI
C0207661
FDA_UNII_Code
319R5C7293
prefixIRI
NCIT:C1461
NCI_Drug_Dictionary_ID
42334
Contributing_Source
CRCH
CTRP
FDA
subClassOf
CHEBI_ID
CHEBI:10782
CHEBI:15420
code
C1461
type
ALT_DEFINITION
A substance that is being studied in the prevention of cancer. It belongs to the family of plant drugs called monoterpenes.
A terpene with two isoprene units forming a ring and with a hydroxyl group attached to the head methyl group. The chemical structure is CC(=C)C1CCC(=CC1)CO.
NSC Number
641066
PDQ_Closed_Trial_Search_ID
42334
Semantic_Type
Organic Chemical
Pharmacologic Substance
CAS_Registry
18457-55-1
536-59-4
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