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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1442
http://purl.obolibrary.org/obo/NCIT_C1442
|
|---|---|
| Preferred Name | Morpholinodoxorubicin |
| Definitions |
A semisynthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin. As an antineoplastic agent, morpholinodoxorubicin is more potent than doxorubicin. Similar to doxorubicin, morpholinodoxorubicin intercalates into DNA and causes single- and double-strand breaks in DNA via inhibition of topoisomerase I and II. Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin. As an antineoplastic agent, morpholinodoxorubicin is more potent than doxorubicin. Similar to doxorubicin, morpholinodoxorubicin intercalates into DNA and causes single- and double-strand breaks in DNA via inhibition of topoisomerase I and II. Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity. (NCI04) |
|---|---|
| label | Morpholinodoxorubicin
|
| prefLabel | Morpholinodoxorubicin
|
| Legacy Concept Name | Morpholinodoxorubicin
|
| in_subset | |
| Preferred_Name | Morpholinodoxorubicin
|
| Is_Value_For_GDC_Property | |
| Maps_To | Morpholinodoxorubicin
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| UMLS_CUI | C0173377
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| FDA_UNII_Code | X0N4EFN4AI
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| prefixIRI | NCIT:C1442
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1442
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| type | |
| NSC Number | 354646
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| CAS_Registry | 89196-04-3
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