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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1441
http://purl.obolibrary.org/obo/NCIT_C1441
|
|---|---|
| Preferred Name | Carzelesin |
| Definitions |
A cyclopropylpyrroloindole prodrug analogue and DNA minor groove binding agent, with antineoplastic activity. After hydrolysis, the cyclopropyl group of carzelesin alkylates N3-adenine in a sequence-selective fashion. This results in tumor growth inhibition.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cyclopropylpyrroloindole prodrug analogue and DNA minor groove binding agent, with antineoplastic activity. After hydrolysis, the cyclopropyl group of carzelesin alkylates N3-adenine in a sequence-selective fashion. This results in tumor growth inhibition. |
|---|---|
| prefLabel | Carzelesin
|
| label | Carzelesin
|
| PDQ_Closed_Trial_Search_ID | 42571
|
| code | C1441
|
| prefixIRI | NCIT:C1441
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| in_subset | |
| Preferred_Name | Carzelesin
|
| FDA_UNII_Code | 668UF07O1P
|
| Contributing_Source | FDA
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| Chemical_Formula | C41H37ClN6O5
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| Maps_To | Carzelesin
|
| CAS_Registry | 119813-10-4
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| NSC Number | 619029
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| NCI_Drug_Dictionary_ID | 42571
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| Legacy Concept Name | Carzelesin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42571
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0172048
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| Delete | Subject | Author | Type | Created |
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