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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1440
http://purl.obolibrary.org/obo/NCIT_C1440
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|---|---|
| Preferred Name | Sodium Phenylbutyrate |
| Definitions |
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. |
|---|---|
| prefLabel | Sodium Phenylbutyrate
|
| label | Sodium Phenylbutyrate
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| PDQ_Closed_Trial_Search_ID | 536018
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| code | C1440
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| Has_Target | |
| prefixIRI | NCIT:C1440
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| in_subset |
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| Display_Name | Sodium Phenylbutyrate
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| Preferred_Name | Sodium Phenylbutyrate
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| FDA_UNII_Code | NT6K61736T
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C10H11O2.Na
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| Maps_To | Sodium Phenylbutyrate
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| CAS_Registry | 1716-12-7
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| NSC Number | 657802
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| NCI_Drug_Dictionary_ID | 536018
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| Legacy Concept Name | _4-Phenylbutyrate
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called differentiating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 536018
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| Accepted_Therapeutic_Use_For | Adjunctive therapy for urea cycle disorders involving deficiencies of carbamoylphosphate synthetase; ornithine transcarbamylase; or argininosuccinic acid synthetase; S-S and S-C sickle cell disease; S-thalassemia hemoglobinopathy
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0718066
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