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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1439
http://purl.obolibrary.org/obo/NCIT_C1439
|
|---|---|
| Preferred Name | Dolastatin 15 |
| Definitions |
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04) |
|---|---|
| prefLabel | Dolastatin 15
|
| label | Dolastatin 15
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| code | C1439
|
| prefixIRI | NCIT:C1439
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| in_subset | |
| Preferred_Name | Dolastatin 15
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| FDA_UNII_Code | J9ZKS885H5
|
| Contributing_Source | FDA
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| Maps_To | Dolastatin 15
|
| CAS_Registry | 123884-00-4
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| NSC Number | 617668
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| Legacy Concept Name | Dolastatin_15
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0170214
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