Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1438
http://purl.obolibrary.org/obo/NCIT_C1438
Preferred Name

Troxacitabine
Definitions
A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation.
prefLabel
Troxacitabine
label
Troxacitabine
PDQ_Closed_Trial_Search_ID
43646
code
C1438
prefixIRI
NCIT:C1438
in_subset
Display_Name
Troxacitabine
Preferred_Name
Troxacitabine
FDA_UNII_Code
60KQZ0388Y
Contributing_Source
CTRP
FDA
Chemical_Formula
C8H11N3O4
Maps_To
Troxacitabine
CAS_Registry
145918-75-8
NCI_Drug_Dictionary_ID
43646
Legacy Concept Name
Troxacitabine
type
ALT_DEFINITION
A drug being studied for use as an anticancer agent.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
43646
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C0877874
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