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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1437
http://purl.obolibrary.org/obo/NCIT_C1437
|
|---|---|
| Preferred Name | Recombinant CD40-Ligand |
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. (NCI04) |
|---|---|
| prefLabel | Recombinant CD40-Ligand
|
| label | Recombinant CD40-Ligand
|
| PDQ_Closed_Trial_Search_ID | 43639
|
| code | C1437
|
| prefixIRI | NCIT:C1437
|
| in_subset | |
| Preferred_Name | Recombinant CD40-Ligand
|
| Maps_To | Recombinant CD40-Ligand
|
| CAS_Registry | 147205-72-9
|
| NSC Number | 696600
|
| NCI_Drug_Dictionary_ID | 43639
|
| Legacy Concept Name | Therapeutic_CD40-Ligand
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43639
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
|
| UMLS_CUI | C1527003
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| Delete | Subject | Author | Type | Created |
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| No notes to display |