Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1431
http://purl.obolibrary.org/obo/NCIT_C1431
Preferred Name

Imiquimod
Definitions
A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)
prefLabel
Imiquimod
label
Imiquimod
CHEBI_ID
CHEBI:36704
PDQ_Closed_Trial_Search_ID
38558
code
C1431
prefixIRI
NCIT:C1431
in_subset
Display_Name
Imiquimod
Preferred_Name
Imiquimod
FDA_UNII_Code
P1QW714R7M
Contributing_Source
CTRP
FDA
Chemical_Formula
C14H16N4
Maps_To
Imiquimod
CAS_Registry
99011-02-6
NSC Number
369100
741062
NCI_Drug_Dictionary_ID
38558
Legacy Concept Name
Imiquimod
type
ALT_DEFINITION
A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Imiquimod is a type of biological response modifier.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
38558
Accepted_Therapeutic_Use_For
Condyloma; Superficial Basal Cell Carcinoma; Actinic Keratosis
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0718327
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