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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1418
http://purl.obolibrary.org/obo/NCIT_C1418
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|---|---|
| Preferred Name | Clodronate Disodium |
| Definitions |
The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain. |
|---|---|
| prefLabel | Clodronate Disodium
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| label | Clodronate Disodium
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| CHEBI_ID | CHEBI:59587
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| PDQ_Closed_Trial_Search_ID | 41862
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| code | C1418
|
| prefixIRI | NCIT:C1418
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| in_subset |
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| Display_Name | Clodronate Disodium
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| Preferred_Name | Clodronate Disodium
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| FDA_UNII_Code | N030400H8J
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | CH2Cl2O6P2.2Na.4H2O
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| Maps_To | Clodronate Disodium
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| CAS_Registry | 88416-50-6
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| NSC Number | 713466
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| NCI_Drug_Dictionary_ID | 41862
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| Legacy Concept Name | Clodronate_Disodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases). It may decrease pain, the risk of fractures, and the development of new bone metastases.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41862
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| Accepted_Therapeutic_Use_For | Adjuvant usage in bone metastasis of Breast cancer
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0008994
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