Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1413
http://purl.obolibrary.org/obo/NCIT_C1413
Preferred Name

Topotecan
Definitions
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
prefLabel
Topotecan
label
Topotecan
Has_Salt_Form
CHEBI_ID
CHEBI:63632
code
C1413
Has_Target
prefixIRI
NCIT:C1413
in_subset
Display_Name
Topotecan
Preferred_Name
Topotecan
FDA_UNII_Code
7M7YKX2N15
Contributing_Source
CTRP
FDA
Chemical_Formula
C23H23N3O5
Maps_To
Topotecan
CAS_Registry
123948-87-8
NSC Number
641007
Legacy Concept Name
Topotecan
type
ALT_DEFINITION
A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0146224
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