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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C141074
http://purl.obolibrary.org/obo/NCIT_C141074
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|---|---|
| Preferred Name | ERK1/2 Inhibitor KO-947 |
| Definitions |
An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, KO-947 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, KO-947 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells. |
|---|---|
| prefLabel | ERK1/2 Inhibitor KO-947
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| label | ERK1/2 Inhibitor KO-947
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| NCI_META_CUI | CL539120
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| PDQ_Closed_Trial_Search_ID | 791296
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| code | C141074
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| Has_Target | |
| prefixIRI | NCIT:C141074
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| in_subset |
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| Display_Name | ERK1/2 Inhibitor KO-947
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| Preferred_Name | ERK1/2 Inhibitor KO-947
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| Contributing_Source | CTRP
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| Maps_To | ERK1/2 Inhibitor KO-947
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| NCI_Drug_Dictionary_ID | 791296
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 791296
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| Semantic_Type | Pharmacologic Substance
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