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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1405
http://purl.obolibrary.org/obo/NCIT_C1405
|
|---|---|
| Preferred Name | Valspodar |
| Definitions |
An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04) |
|---|---|
| prefLabel | Valspodar
|
| label | Valspodar
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| PDQ_Closed_Trial_Search_ID | 41750
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| code | C1405
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| Has_Target | |
| prefixIRI | NCIT:C1405
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| in_subset |
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| Display_Name | Valspodar
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| Preferred_Name | Valspodar
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| FDA_UNII_Code | Q7ZP55KF3X
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C63H111N11O12
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| Maps_To | Valspodar
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| CAS_Registry | 121584-18-7
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| NSC Number | 648265
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| NCI_Drug_Dictionary_ID | 41750
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| Legacy Concept Name | Valspodar
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| type | |
| ALT_DEFINITION | A substance that is being studied for its ability to prevent or overcome the resistance of tumor cells to some anticancer drugs. It belongs to the family of drugs called cyclosporine analogs.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41750
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0753474
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