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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1400
http://purl.obolibrary.org/obo/NCIT_C1400
|
|---|---|
| Preferred Name | Peplomycin Sulfate |
| Definitions |
The sulfate salt of the bleomycin analogue peplomycin. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sulfate salt of the bleomycin analogue peplomycin. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04) |
|---|---|
| prefLabel | Peplomycin Sulfate
|
| label | Peplomycin Sulfate
|
| code | C1400
|
| prefixIRI | NCIT:C1400
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| in_subset | |
| Preferred_Name | Peplomycin Sulfate
|
| FDA_UNII_Code | 6A668951HW
|
| Contributing_Source | FDA
|
| Chemical_Formula | C61H88N18O21S2.H2O4S
|
| Maps_To | Peplomycin Sulfate
|
| CAS_Registry | 73228-94-1
|
| Legacy Concept Name | Peplomycin_Sulfate
|
| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0917878
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