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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1399
http://purl.obolibrary.org/obo/NCIT_C1399
|
|---|---|
| Preferred Name | Peplomycin |
| Definitions |
A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04) |
|---|---|
| prefLabel | Peplomycin
|
| label | Peplomycin
|
| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39552
|
| code | C1399
|
| prefixIRI | NCIT:C1399
|
| in_subset | |
| Preferred_Name | Peplomycin
|
| FDA_UNII_Code | 56H9L80NIZ
|
| Contributing_Source | FDA
|
| Chemical_Formula | C61H88N18O21S2
|
| Maps_To | Peplomycin
|
| CAS_Registry | 68247-85-8
|
| NSC Number | 276382
|
| NCI_Drug_Dictionary_ID | 39552
|
| Legacy Concept Name | Peplomycin
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39552
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Antibiotic
|
| UMLS_CUI | C0135981
|
| Delete | Subject | Author | Type | Created |
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| No notes to display |