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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C139552
http://purl.obolibrary.org/obo/NCIT_C139552
|
|---|---|
| Preferred Name | Mevociclib |
| Definitions |
A selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic activity. Upon administration, SY-1365 binds to and inhibits CDK7, thereby inhibiting CDK7-mediated signal transduction pathways. This inhibits cell growth of CDK7-overexpressing tumor cells. CDK7, a serine/threonine kinase, plays a key role in cell proliferation; CDK7 is overexpressed in a variety of tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A selective inhibitor of cyclin-dependent kinase 7 (CDK7), with potential antineoplastic activity. Upon administration, SY-1365 binds to and inhibits CDK7, thereby inhibiting CDK7-mediated signal transduction pathways. This inhibits cell growth of CDK7-overexpressing tumor cells. CDK7, a serine/threonine kinase, plays a key role in cell proliferation; CDK7 is overexpressed in a variety of tumor cell types. |
|---|---|
| prefLabel | Mevociclib
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| label | Mevociclib
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| NCI_META_CUI | CL526907
|
| PDQ_Closed_Trial_Search_ID | 791104
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| code | C139552
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| Has_Target | |
| prefixIRI | NCIT:C139552
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| in_subset |
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| Display_Name | Mevociclib
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| Preferred_Name | Mevociclib
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| FDA_UNII_Code | 704LW082GI
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
CDK7 Inhibitor SY-1365
Mevociclib
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| CAS_Registry | 1816989-16-8
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| NCI_Drug_Dictionary_ID | 791104
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 791104
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| Semantic_Type | Pharmacologic Substance
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