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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C139549
http://purl.obolibrary.org/obo/NCIT_C139549
|
|---|---|
| Preferred Name | Cevostamab |
| Definitions |
A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) Fc receptor-like protein 5 (FCRH5; CD307; FCRL5; IRTA2; BXMAS1) and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of cevostamab, the bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and FCRH5 found on FCRH5-expressing tumor cells. This activates and crosslinks CTLs with FCRH5-expressing tumor cells, which results in the CTL-mediated cell death of FCRH5-expressing tumor cells. FCRH5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FCRH) family member and a B-cell lineage marker, is overexpressed on myeloma cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) Fc receptor-like protein 5 (FCRH5; CD307; FCRL5; IRTA2; BXMAS1) and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of cevostamab, the bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and FCRH5 found on FCRH5-expressing tumor cells. This activates and crosslinks CTLs with FCRH5-expressing tumor cells, which results in the CTL-mediated cell death of FCRH5-expressing tumor cells. FCRH5, an immune receptor translocation-associated protein/Fc receptor homolog (IRTA/FCRH) family member and a B-cell lineage marker, is overexpressed on myeloma cells. |
|---|---|
| prefLabel | Cevostamab
|
| label | Cevostamab
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| NCI_META_CUI | CL526909
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| PDQ_Closed_Trial_Search_ID | 791048
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| code | C139549
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| Has_Target | |
| prefixIRI | NCIT:C139549
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| in_subset |
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| Display_Name | Cevostamab
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| Preferred_Name | Cevostamab
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| FDA_UNII_Code | P86BHN01VE
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Anti-FCRH5/CD3 BiTE Antibody BFCR4350A
Cevostamab
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| CAS_Registry | 2249888-53-5
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| NCI_Drug_Dictionary_ID | 791048
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 791048
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| Semantic_Type | Pharmacologic Substance
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