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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1390
http://purl.obolibrary.org/obo/NCIT_C1390
|
|---|---|
| Preferred Name | Merbarone |
| Definitions |
A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes. |
|---|---|
| prefLabel | Merbarone
|
| label | Merbarone
|
| PDQ_Closed_Trial_Search_ID | 40220
|
| code | C1390
|
| prefixIRI | NCIT:C1390
|
| in_subset | |
| Preferred_Name | Merbarone
|
| FDA_UNII_Code | YWB9IF596V
|
| Contributing_Source | FDA
|
| Maps_To | Merbarone
|
| CAS_Registry | 97534-21-9
|
| NSC Number | 336628
|
| NCI_Drug_Dictionary_ID | 40220
|
| Legacy Concept Name | Merbarone
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40220
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0127565
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| Delete | Subject | Author | Type | Created |
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