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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C138994
http://purl.obolibrary.org/obo/NCIT_C138994
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|---|---|
| Preferred Name | Copanlisib Hydrochloride |
| Definitions |
The dihydrochloride salt form of copanlisib, a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The dihydrochloride salt form of copanlisib, a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. |
|---|---|
| prefLabel | Copanlisib Hydrochloride
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| label | Copanlisib Hydrochloride
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| NCI_META_CUI | CL526449
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| PDQ_Closed_Trial_Search_ID | 653981
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| code | C138994
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| Has_Target | |
| prefixIRI | NCIT:C138994
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| in_subset |
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| Display_Name | Copanlisib Hydrochloride
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| Preferred_Name | Copanlisib Hydrochloride
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| FDA_UNII_Code | 03ZI7RZ52O
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Copanlisib Hydrochloride
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| CAS_Registry | 1402152-13-9
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| NCI_Drug_Dictionary_ID | 653981
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 653981
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| Semantic_Type | Pharmacologic Substance
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