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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1380
http://purl.obolibrary.org/obo/NCIT_C1380
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|---|---|
| Preferred Name | Edodekin alfa |
| Definitions |
A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Edodekin alfa binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Edodekin alfa binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04) |
|---|---|
| prefLabel | Edodekin alfa
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| label | Edodekin alfa
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| PDQ_Closed_Trial_Search_ID | 42153
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| code | C1380
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| Has_Target | |
| prefixIRI | NCIT:C1380
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| in_subset |
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| Display_Name | Edodekin alfa
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| Preferred_Name | Edodekin alfa
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| FDA_UNII_Code | 31Z82G8ME1
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| Contributing_Source |
CTRP
FDA
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| Maps_To |
Edodekin alfa
Recombinant Interleukin-12
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| CAS_Registry | 187348-17-0
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| NSC Number | 672423
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| NCI_Drug_Dictionary_ID | 42153
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| Legacy Concept Name | Therapeutic_Interleukin-12
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| type | |
| ALT_DEFINITION | One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages. It causes other immune cells to make cytokines and increases the growth of T lymphocytes. It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-12 is a type of cytokine.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42153
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1524115
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