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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1377
http://purl.obolibrary.org/obo/NCIT_C1377
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|---|---|
| Preferred Name | Hematoporphyrin Derivative |
| Definitions |
A complex mixture of monomeric and aggregated porphyrins with photosensitizing activity. Upon systemic administration, hematoporphyrin derivatives accumulate in tumor cells and, once activated by red laser light (630 nm), in the presence of oxygen, produce singlet oxygen and other reactive oxygen radicals, resulting in local radical-mediated tumor cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A complex mixture of monomeric and aggregated porphyrins with photosensitizing activity. Upon systemic administration, hematoporphyrin derivatives accumulate in tumor cells and, once activated by red laser light (630 nm), in the presence of oxygen, produce singlet oxygen and other reactive oxygen radicals, resulting in local radical-mediated tumor cell death. |
|---|---|
| prefLabel | Hematoporphyrin Derivative
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| label | Hematoporphyrin Derivative
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| PDQ_Closed_Trial_Search_ID | 40859
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| code | C1377
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| prefixIRI | NCIT:C1377
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| in_subset | |
| Preferred_Name | Hematoporphyrin Derivative
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| Maps_To | Hematoporphyrin Derivative
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| CAS_Registry | 68335-15-9
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| NSC Number | 265328
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| NCI_Drug_Dictionary_ID | 40859
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| Legacy Concept Name | Hematoporphyrin_Derivative
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| type | |
| ALT_DEFINITION | A drug used in photodynamic therapy that is absorbed by tumor cells. When exposed to light, it becomes active and kills the cancer cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 40859
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0121300
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