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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C13737
http://purl.obolibrary.org/obo/NCIT_C13737
|
|---|---|
| Preferred Name | 20S Proteasome |
| Definitions |
The 20S proteasome, as proteolytic core of the proteasome system, is essential in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD). The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the ATP ubiquitin degradation pathway.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The 20S proteasome, as proteolytic core of the proteasome system, is essential in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD). The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the ATP ubiquitin degradation pathway. |
|---|---|
| prefLabel | 20S Proteasome
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| label | 20S Proteasome
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| code | C13737
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| prefixIRI | NCIT:C13737
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| in_subset | |
| Display_Name | 20S Proteasome
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| Preferred_Name | 20S Proteasome
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| Contributing_Source | CTRP
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| Legacy Concept Name | _20S_Proteasome
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Cell Component
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| UMLS_CUI | C0208355
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