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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1367
http://purl.obolibrary.org/obo/NCIT_C1367
|
|---|---|
| Preferred Name | Elliptinium Acetate |
| Definitions |
Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. |
|---|---|
| label | Elliptinium Acetate
|
| prefLabel | Elliptinium Acetate
|
| Has_Free_Acid_Or_Base_Form | |
| Legacy Concept Name | Elliptinium
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| in_subset | |
| Preferred_Name | Elliptinium Acetate
|
| Is_Value_For_GDC_Property | |
| Chemical_Formula | C18H17N2O.C2H3O2
|
| Maps_To | Elliptinium Acetate
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| PDQ_Open_Trial_Search_ID | 39231
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| UMLS_CUI | C0100593
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| FDA_UNII_Code | H9B41234P4
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| prefixIRI | NCIT:C1367
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| NCI_Drug_Dictionary_ID | 39231
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| Contributing_Source | FDA
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| subClassOf | |
| code | C1367
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| type | |
| NSC Number | 264137
|
| PDQ_Closed_Trial_Search_ID | 39231
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| CAS_Registry | 58337-35-2
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